Table 1.
Measurements of metric trends through aging
| Metric | Control | Cpt2−/− | P Value | IQR Ratio | Trend AUC | 95% CI Interval | Metric AUC |
|---|---|---|---|---|---|---|---|
| n | 14 | 12 | |||||
| End-diastolic volume | 0.711 [0.187, 1.194] | 5.826 [2.537, 16.037] | 0.0001 | 13.40 | 0.946 | 8.96 | 0.720 |
| Peak-systolic volume | 0.265 [0.048, 0.603] | 5.768 [1.850, 16.034] | 0.0000 | 25.57 | 0.988 | 8.64 | 0.789 |
| Stroke volume | 0.397 [0.037, 0.802] | 0.281 [−0.086, 0.687] | 0.6620 | 1.01 | 0.554 | – | 0.536 |
| Ejection fraction | −0.205 [−0.741, 0.216] | −3.364 [−6.559 ,−1.633] | 0.0000 | 5.15 | 1.000 | 7.11 | 0.839 |
| Left ventricle mass | 2.078 [1.299, 2.525] | 9.302 [8.599, 25.402] | 0.0000 | 13.71 | 0.988 | DNO | 0.949 |
| LV wall thickness | 0.007 [0.003, 0.010] | 0.024 [0.002, 0.034] | 0.0760 | 4.85 | 0.708 | DNO | 0.981 |
| Peak Eθθ | |||||||
| Base | 0.106 [−0.093, 0.404] | 1.586 [1.065, 3.148] | 0.0000 | 4.19 | 0.988 | 6.52 | 0.861 |
| Mid-LV | 0.181 [−0.157, 0.435] | 1.712 [0.670, 3.346] | 0.0002 | 4.52 | 0.929 | 8.30 | 0.730 |
| Apical | 0.007 [−0.126, 0.338] | 1.787 [0.414, 2.840] | 0.0037 | 5.22 | 0.839 | 9.77 | 0.652 |
| Peak ELL | |||||||
| Ant. FW | 0.168 [−0.006, 0.429] | 0.898 [0.547, 1.118] | 0.0002 | 1.31 | 0.929 | 4.58 | 0.903 |
| Anterior | 0.129 [−0.043, 0.396] | 0.893 [0.496, 1.089] | 0.0002 | 1.35 | 0.940 | 6.06 | 0.860 |
| Ant. Sep. | 0.160 [−0.026, 0.361] | 0.845 [0.509, 1.115] | 0.0001 | 1.57 | 0.952 | 6.91 | 0.821 |
| Post. Sep | 0.062 [−0.034, 0.263] | 1.068 [0.641, 1.314] | 0.0000 | 2.27 | 0.976 | 6.17 | 0.880 |
| Posterior | 0.069 [−0.064, 0.427] | 1.223 [0.708, 1.684] | 0.0000 | 1.99 | 0.982 | 5.27 | 0.913 |
| Post. FW | 0.155 [−0.041, 0.478] | 1.002 [0.594, 1.254] | 0.0001 | 1.27 | 0.952 | 4.86 | 0.909 |
| Hybrid strain index | −0.100 [−0.445, 0.180] | −1.893 [−3.723, −1.261] | 0.0000 | 3.94 | 1.000 | 5.72 | 0.907 |
For each cohort, medians [interquartile ranges] are provided for control (n = 14) and Cpt2M−/− (n = 12) mice, along with P values from Mann–Whitney tests, ratio of interquartile ranges (IQR) in Cpt2M−/− and control trends, area under curve (AUC) values, and the 95% confidence interval (CI) intersection locations. Metrics where 95% confidence intervals overlapped for the entire age range of the study were noted with “–”, and metrics where 95% confidence intervals did not overlap are noted with “DNO.” FW, free-wall; LV, left ventricle.