Figure 3.

Body weight and energy intake patterns of male and female wildt-ype (WT) and myoglobin (Mb) KO mice fed a high-fat diet (45% of energy) for ∼13 wk. A: body weights of mice over the course of the study. Dotted vertical lines indicate when respiratory exchange ratio (RER) and energy expenditure were measured using an indirect calorimetry CLAMS instrument. B: cumulative energy intake (kcal) of mice during a time period that had the lowest number of excess spillage days (many mice in the study spilled food for much of the time frame, allowing only a subset of days to be analyzed with accuracy). Values depict means ± SE. Body weight: males, n = 10 per group; females, n = 9 per group. Energy intake: males, n = 9–10 per group; females n = 7–9 per group. HFD, high-fat diet (45% of energy).