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. 2021 May 10;321(1):E63–E79. doi: 10.1152/ajpendo.00624.2020

Table 8.

Skeletal muscle transcript abundances that differed significantly when comparing wild-type and myoglobin knockout mice following ∼13 wk of feeding a high-fat diet (45% of energy)

Mb−/− as a % of WTa FDR-Adjusted P Valueb
Female gastrocnemiusc,d
 Phospho1 88% 0.0006
 Hsph1 77% 0.013
Female soleus
 Tfrc 80% 0.0002
 Pygo1 111% 0.002
 Fn1 91% 0.0085
 Adamts9 72% 0.037
 Serpinh1 92% 0.037
 Mitf 108% 0.043
 Myadm 88% 0.045
Male soleuse
 Dapp1 144% 0.001
 Tm6sf1 125% 0.0018
 Arpp21 119% 0.002
 St3gal2 90% 0.0027
 Gm15543 142% 0.007
 Sorl1 111% 0.010
 Plce1 111% 0.0125
 Catsper4 71% 0.0125
 Armh4 80% 0.015
 Obsl1 89% 0.020
 Fam198b 120% 0.020
 Kcnq4 110% 0.020
 Acan 197% 0.020
 Barx2 113% 0.020
 Aldh1b1 141% 0.020
 Ssx2ip 115% 0.020
 Gm5105 148% 0.020
 Mfsd4a 146% 0.020
 Lyrm9 119% 0.020
 Tfrc 82% 0.022
 Chrna4 312% 0.022
 Zfp750 192% 0.022
 Lrtm1 113% 0.028
 Igfbp2 218% 0.030
 Adcy2 110% 0.033
 Ern1 86% 0.034
AI838599 76% 0.045
 1700025GRik 89% 0.045
*

Excluding myoglobin transcript and including only transcripts with FDR-corrected P ≤ 0.05. Mb−/−,myoglobin knockout; WT, wildtype.

a

Calculated as: % of WT = 2^(log2 fold change) × 100.

b

False discovery rate-adjusted pvalue, from iDEP output.

c

Females: results derived from n = 9 WT and n = 9 Mb−/−, except soleus where n = 8 Mb−/− due to outlier removal (detected by principal component analysis).

d

There were no statistically significant differences in male gastrocnemius.

e

Males: results derived from n = 10 WT and n = 10 Mb−/−.