Table 8.
Skeletal muscle transcript abundances that differed significantly when comparing wild-type and myoglobin knockout mice following ∼13 wk of feeding a high-fat diet (45% of energy)
| Mb−/− as a % of WTa | FDR-Adjusted P Valueb | |
|---|---|---|
| Female gastrocnemiusc,d | ||
| Phospho1 | 88% | 0.0006 |
| Hsph1 | 77% | 0.013 |
| Female soleus | ||
| Tfrc | 80% | 0.0002 |
| Pygo1 | 111% | 0.002 |
| Fn1 | 91% | 0.0085 |
| Adamts9 | 72% | 0.037 |
| Serpinh1 | 92% | 0.037 |
| Mitf | 108% | 0.043 |
| Myadm | 88% | 0.045 |
| Male soleuse | ||
| Dapp1 | 144% | 0.001 |
| Tm6sf1 | 125% | 0.0018 |
| Arpp21 | 119% | 0.002 |
| St3gal2 | 90% | 0.0027 |
| Gm15543 | 142% | 0.007 |
| Sorl1 | 111% | 0.010 |
| Plce1 | 111% | 0.0125 |
| Catsper4 | 71% | 0.0125 |
| Armh4 | 80% | 0.015 |
| Obsl1 | 89% | 0.020 |
| Fam198b | 120% | 0.020 |
| Kcnq4 | 110% | 0.020 |
| Acan | 197% | 0.020 |
| Barx2 | 113% | 0.020 |
| Aldh1b1 | 141% | 0.020 |
| Ssx2ip | 115% | 0.020 |
| Gm5105 | 148% | 0.020 |
| Mfsd4a | 146% | 0.020 |
| Lyrm9 | 119% | 0.020 |
| Tfrc | 82% | 0.022 |
| Chrna4 | 312% | 0.022 |
| Zfp750 | 192% | 0.022 |
| Lrtm1 | 113% | 0.028 |
| Igfbp2 | 218% | 0.030 |
| Adcy2 | 110% | 0.033 |
| Ern1 | 86% | 0.034 |
| AI838599 | 76% | 0.045 |
| 1700025GRik | 89% | 0.045 |
*
Excluding myoglobin transcript and including only transcripts with FDR-corrected P ≤ 0.05. Mb−/−,myoglobin knockout; WT, wildtype.
a
Calculated as: % of WT = 2^(log2 fold change) × 100.
b
False discovery rate-adjusted pvalue, from iDEP output.
c
Females: results derived from n = 9 WT and n = 9 Mb−/−, except soleus where n = 8 Mb−/− due to outlier removal (detected by principal component analysis).
d
There were no statistically significant differences in male gastrocnemius.
e
Males: results derived from n = 10 WT and n = 10 Mb−/−.