FIGURE 3.

Risk of bias assessments in alphabetical order of first authors’ names. Panel A: randomized studies using Cochrane's Risk of Bias tool. Panel B: nonrandomized studies using the ROBINS-I tool. Low (green): judged to be at low risk of bias for all domains. Some (yellow): judged to raise some concerns in ≥1 domain, but not to be at high risk of bias for any domain. High (red): judged to be at high risk of bias in ≥1 domain for this result OR the study is judged to have some concerns for multiple domains in a way that substantially lowers confidence in the result. ROBINS-I, Risk of Bias in Non-Randomised Studies-of Interventions.