Figure 5.
Loss of serum response factor (SRF) in lung mesenchymal cells does not affect the early inflammatory response to bleomycin injury. Tbx4LE-rtTA/TetO-Cre/tdTom and Tbx4LE-rtTA/TetO-Cre/tdTom/SRFf,f were given doxycycline (dox, 2 mg/mL + 50 mg/mL sucrose) or control (50 mg/mL sucrose) in water 2 days before an intratracheal instillation of 1 U/kg bleomycin (Bleo) or normal saline. A: 3 days after bleomycin treatment, bronchoalveolar lavage cells were collected and cell differential counts obtained. B: animals were weighed daily until end point (day 14) to compare rates of weight loss between groups. N for each group is indicated in the figure. One-way ANOVA with Holm–Šídák test (P < 0.05) was used for statistical analyses.