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. 2021 May 19;321(1):L102–L115. doi: 10.1152/ajplung.00618.2020

Figure 1.

Figure 1.

Recombinant furin (rFurin) prevents inflammatory signaling pathways in airway smooth muscle tissues. Airway smooth muscle tissues were treated with 0.5 µg/mL furin overnight and then incubated with or without 50 ng/mL IL-13 overnight or for 30 min. A: eotaxin secretion was significantly increased by stimulation with IL-13 (n = 6, P = 0.0001). rFurin significantly inhibited IL-13-induced eotaxin secretion (n = 6, P = 0.0133). B: IL-13 significantly increases Akt phosphorylation (n = 9, P = 0.0001). Furin significantly inhibits Akt phosphorylation induced by IL-13 (n = 9, P = 0.0001). C: expression of smooth muscle myosin heavy chain (SmMHC) was significantly inhibited in tissues stimulated with IL-13 (n = 7, P = 0.0001). Furin prevents inhibition of SmMHC expression induced by IL-13 (n = 7, P = 0.2526). All statistical analyses were performed by using one-way ANOVA with repeated measures. Values are means ± SE. *Significant difference between groups. rFu, rFurin; US, unstimulated.