Figure 6.

Mean organoid responses correlated with clinical trial data. Pearson’s correlation of the organoid swelling response to the clinical trial mean change in sweat Cl⁻ (ΔSwCl⁻; A) and to the clinical trial matched absolute change in percent predicted forced expiratory volume in 1 s (ΔppFEV₁; B). The dashed vertical line represents 10% modulator improvement from baseline as a percentage of the non-cystic fibrosis (non-CF) response [wild type (WT)]. C: clinical trial details corresponding to the numbers above each data point in A and B. The forskolin-induced swelling (FIS) area under the curve (AUC) percent in the WT column corresponds to the mean (SD) drug response of the subjects listed in the last column. These subject codes correspond with the subject codes provided in Supplemental Table S1. CFTR, CF transmembrane conductance regulator; elex/tez/iva, elexacaftor/tezacaftor/ivacaftor; iva, ivacaftor; tez/iva, tezacaftor/ivacaftor.