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. 2021 Jun 23;40(30):4906–4918. doi: 10.1038/s41388-021-01891-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap showed the top ten upregulated and downregulated mRNAs in paclitaxel-resistant OV3R-PTX cells compared with paclitaxel-sensitive OVCAR-3 cells by a cutoff value of more than 2-fold. B Top ten upregulated mRNAs in the microarray were confirmed by qRT-PCR. ***, p < 0.001. C Analysis of the top 50 upregulated mRNAs and proteins from transcriptomes and proteomics. SRI and MDR1 were overexpressed both at mRNA and protein levels in OV3R-PTX cells. D SRI protein expression in OVCAR-3 and OV3R-PTX cells detected by Western blot. E SRI protein expression in SKOV-3 and SK3R-PTX cells detected by Western blot. F Immunofluorescence staining of SRI in OVCAR-3 and OV3R-PTX cells. G Immunofluorescence staining of SRI in SKOV3 and SK3R-PTX cells. H Representative images of SRI protein expression in primary ovarian cancer and non-tumorous ovarian tissue by immunohistochemistry. Original magnification, ×20. I Comparison of SRI protein expression between non-tumorous ovarian tissues (n = 9) and OC tissues (n = 20). J Comparison of SRI mRNA expression between chemotherapy-sensitive (n = 16) and chemotherapy-resistant (n = 12) ovarian serous carcinoma. K Kaplan–Meier analysis of the overall survival of OC patients associated with SRI expression. L Kaplan–Meier analysis of the progression-free survival of OC patients associated with SRI expression.