Table 3.
Sex-specific multivariable HRs for all-cause mortality with individuals with weight change of middle-aged and older adult
| Variable | Age 45–64 y |
Age ≥65 y |
P interaction* | ||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Men | 0.538 | ||||
| Weight change | |||||
| Stable <5 kg | 1 (Reference) | 1 (Reference) | |||
| Gain ≥5 kg | 0.99 (0.56–1.73) | 0.970 | 1.05 (0.77–1.42) | 0.776 | |
| Loss ≥5 kg | 1.94 (1.20–3.12) | 0.007 | 1.60 (1.23–2.08) | <0.001 | |
| Women | 0.952 | ||||
| Weight change | |||||
| Stable <5 kg | 1 (Reference) | 1 (Reference) | |||
| Gain ≥5 kg | 0.67 (0.26–1.74) | 0.409 | 0.98 (0.71–1.36) | 0.914 | |
| Loss ≥5 kg | 1.25 (0.61–2.57) | 0.540 | 1.56 (1.17–2.08) | 0.002 | |
| P-interaction† | <0.001 | <0.001 | |||
Analyzed using Cox proportional hazards regression models. Adjusted by age, sex, marital status, education level, income level, multimorbidity, smoking, alcohol, BMI, ADL, IADL, and MMSE. Age, BMI, ADL, and IADL are continuous variables.
HR, hazard ratio; CI, confidential interval; BMI, body mass index; ADL, activities of daily living; IADL, instrumental activities of daily living; MMSE, Mini-Mental State Examination.
*
P-value for interaction between age group and sex.
†
P-value for interaction between weight change and sex.