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The inhibition parameters of the bioactive constituents in AGE against SARS-CoV-2 3CLpro.
| No. | Compound | Structure | IC50 (μM) |
Ratio | KI (μM) | Kinact (min−1) | |
|---|---|---|---|---|---|---|---|
| 0.5 (min) | 60 (min) | ||||||
| 1 | Dihydromyricetin |  |
34.61 | 4.91 | 7.05 | 67.35 | 0.064 |
| 2 | Isodihydromyricetin |  |
29.04 | 3.73 | 7.78 | 62.43 | 0.058 |
| 3 | Myricitrin |  |
118.10 | 14.22 | 8.32 | – | – |
| 4 | Taxifolin |  |
>200 | 72.72 | >2.75 | – | – |
| 5 | Myricetin |  |
21.44 | 1.21 | 17.72 | 6.33 | 0.013 |
| 6 | Ebselena |  |
3.11 | 2.62 | 1.18 | – | – |
A known positive covalent inhibitor for SARS-CoV-2 3CLpro.
