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. 2021 Jul 29;11:15440. doi: 10.1038/s41598-021-94281-7

Table 2.

Relationships between gestational age at delivery, perceived stress, and biological age estimates in the PREG cohort.

Full sample coef Full sample SE Full sample p-value EA subset coef EA subset SE EA subset p-value AA subset coef AA subset SE AA subset p-value
Predicts GAAD
Early BA 0.63 0.21 0.003* 0.40 0.24 0.107 0.71 0.33 0.038
Late BA 0.06 0.18 0.763 -0.11 0.26 0.669 0.03 0.27 0.918
Predicts early prenatal PSS
Early BA -0.35 0.13 0.009 -0.16 0.19 0.389 -0.43 0.17 0.016
Predicts late prenatal PSS
Early BA -0.14 0.14 0.319 -0.11 0.21 0.600 -0.15 0.19 0.435
Late BA -0.09 0.13 0.514 -0.07 0.20 0.715 0.07 0.17 0.669
Predicts late BA
Early PSS -0.08 0.05 0.098 -0.06 0.06 0.365 -0.03 0.08 0.742

Horvath probe sets were reduced to match the probes available for GAPPS.

coef = coefficient, SE = standard error, EA = European American, AA = African American, PSS = perceived stress scale total score, GAAD = gestational age at delivery, BA = Horvath-derived biological age estimates.

Maternal chronological age was included as a covariate in all models.

Survives Bonferroni adjustment for 6 tests, p-val <0.008.