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. 2021 Jul 29;7:197. doi: 10.1038/s41420-021-00543-8

Fig. 4. Loss of TG2 crosslinking activity alters functional responses of cells and tissue.

Fig. 4

A, B Compliance of carotid artery from Tgm2-C277S and WT littermate mice (A), and from age-matched TG2−/− (KO) and WT Bl6/129S mice (B) before and after a remodeling stimulus (n = 8 per cohort; ****p < 0.0001 by Student’s t test). C, D Vascular smooth muscle cell (VSMC) proliferation on collagen I-coated plasticware (n = 5 per group; **p < 0.01 by one-way repeated measures ANOVA). E, F Contraction response of aortic rings from young Tgm2-C277S and WT littermate mice (E), and from age-matched TG2−/− (KO) and WT Bl6/129S mice (F) in response to increasing concentrations of serotonin (5-HT; n = 12 per group; #p < 0.01; **p < 0.01 vs. corresponding WT at same agonist concentration by one-way ANOVA with Bonferroni post hoc analysis). G, H Contraction response of aortic rings from young Tgm2-C277S and WT littermate mice (G), and age-matched TG2−/− (KO) and WT Bl6/129S mice (H) in response to increasing concentrations of U46619 (n = 12 per group).