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. 2021 Jul 29;7:197. doi: 10.1038/s41420-021-00543-8

Fig. 5. Functional effects of GTP, fibronectin/integrin binding are preserved in the aorta and vascular smooth muscle cells (VSMCs) of Tgm2-C277S mice.

Fig. 5

A, B Phenylephrine (PE)-induced contractility of aortic rings from Tgm2-C277S and WT littermate mice (Ai), and from age-matched TG2−/− KO (Aii) and Bl6/129S WT mice (n = 8 animals per group, **p < 0.01, #p < 0.001 by one-way ANOVA with Bonferroni post hoc analysis). B Adhesion and spreading of VSMCs from TG2−/− (KO) and age-matched Bl6/129S WT mice on cell culture plastic (i) and fibronectin-coated cell culture plastic (ii). (n = 6; ****p < 0.0001, by one-way repeated measures ANOVA with Bonferroni post hoc analysis). C Adhesion and spreading of VSMCs from Tgm2-C277S and WT littermate mice on cell culture plastic (i) and fibronectin-coated cell culture plastic (ii). (n = 6; **p < 0.01 by one-way repeated measures ANOVA with Bonferroni post hoc analysis). D Proliferation of VSMCs from TG2−/− (KO) and age-matched Bl6/129S WT mice on cell culture plastic (i) and fibronectin-coated cell culture plastic (ii). (n = 6; ***p < 0.001 by one-way repeated measures ANOVA with Bonferroni post hoc analysis). E Proliferation of VSMCs from Tgm2-C277S and littermate WT mice on cell culture plastic (i) and fibronectin-coated cell culture plastic (ii). (n = 6; **p < 0.01 by one-way repeated measures ANOVA with Bonferroni post hoc analysis). F DNA synthesis proliferation assay on cell culture plastic (i) and fibronectin-coated surface (ii) (n = 6; ****p < 0.0001 by Student’s t test).