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. 2021 Jul 29;12:4677. doi: 10.1038/s41467-021-24940-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A. Left panel: Uniform manifold approximation and projection (UMAP) representation of CD8 T-cell landscape. Each color indicates one of the 13 different clusters. CM central memory, TM transitional memory, EM effector memory, EMRA terminally differentiated T cells, TREG regulatory T cells. B Differential analysis performed using generalized linear mixed model (GLMM) between nonpregnant women (CTR; bar color: salmon; n = 3), uninfected pregnant women (PN; green, n = 10), and infected pregnant women (PP; azure, n = 7). The heat represents arcsine-square-root-transformed cell frequencies that were subsequently normalized per cluster (rows) to mean of zero and standard deviation of one. The color of the heat varies from blue indicating relative underrepresentation to red indicating relative overrepresentation. Bar and numbers at the right indicate significant differentially abundant clusters (green) and adjusted p values. C Statistical analysis of the different cell populations identified as in panel A. Comparison among infected pregnant women (PP) vs. uninfected pregnant (PN) or vs. healthy, nonpregnant donors (CTR). The dot plots show the relative abundancies of 13 populations found within CD8+ T cells. Values (dots) for the three conditions are matched with the color used in B. Data represent individual percentage values (dots), median (center bar), and SEM (upper and lower bars). Generalized linear mixed model (GLMM) with Bonferroni correction has been used. The exact p-value is indicated in the figure. Source data are provided as a Source Data file.