Fig. 5.

CD147 deficiency increases the intratumoral abundance and effector function of CD8⁺ TILs after adoptive transfer. A The counts of CD45.1⁺ CD147^+/+ CD8⁺ or CD45.2⁺ CD147^−/− CD8⁺ T cells per million total intratumoral cells in recipient RAG mice were calculated with flow cytometry (n = 3). B, C The frequencies of perforin⁺, granzyme B⁺, IFN-γ⁺, TNF-α⁺, and PD-1⁺ cells in the total CD45.1⁺CD147^+/+ CD8⁺ or CD45.2⁺ CD147^−/− CD8⁺ TIL population were analyzed with flow cytometry (n = 3). D The frequencies of perforin⁺, granzyme B⁺, IFN-γ⁺, and TNF-α⁺ cells in the PD-1⁺ CD45.1⁺CD147^+/+ CD8⁺ or PD-1⁺ CD45.2⁺ CD147^−/− CD8⁺ TIL population were analyzed with flow cytometry (n = 3)