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. 2021 Jul 29;11:15431. doi: 10.1038/s41598-021-92176-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The in silico immune simulation profile of vaccine which injected 12 doses over a period of 12 months. (A) shows both antigen concentration and relative antibody responses. The efficacy of the vaccination showed by the presence of protective IgGs. (B) shows the corresponding count of antibody generating plasma cells while (C−E) show the activity of macrophages cytotoxic T, and helper T cells.