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. 2021 Jul 16;8:702920. doi: 10.3389/fcvm.2021.702920

Figure 2.

Figure 2

Schematic of the major metabolic pathways that modulate the cardiac regenerative response following injury. Glucose metabolism (blue), fatty acid metabolism (purple), and BCAA metabolism (red). Acetyl CoA from these major metabolic pathways is required for the TCA cycle. GLUT, glucose transporter type; HK, hexokinase; G-6-P, glucose-6-phosphate; F-1,6-BP, fructose-1,6-biphosphate; PFK, phosphofructokinase; PDK, pyruvate dehydrogenase kinase; PDH, pyruvate dehydrogenase; CD36, cluster of differentiation; CPT1, carnitine palmitoyltransferase; MCD, malonyl CoA dehydrogenase; ACC, acetyl CoA carboxylase; BCAAs, branched-chain amino acids; AA, amino acid; BCAT, branched-chain amino-transferase; BCKA, branched-chain alpha keto acids; BCKDH, branched-chain alpha-keto acid dehydrogenase; PP2Cm, protein phosphatase 2Cm; mTOR, the mechanistic target of rapamycin; AMPK, 5′ adenosine monophosphate-activated protein kinase; TCA, tricarboxylic acid cycle; SDH, succinate dehydrogenase. Yellow star induces regeneration and red lightning bolt inhibits regeneration.