Table 1.
The clinicopathological characteristics of cases by anatomic location.
| Total (n = 3010) | Anatomic site | p value | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buccal mucosa (n = 1050) | Alveolar ridge (n = 482) | Ant tongue (n = 884) | Hard palate (n = 87) | Floor of mouth (n = 85) | RMT (n = 158) | Mucosal lip (n = 73) | Body of the lip (n = 191) | ||||||||||||
| N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | ||
| Gender | |||||||||||||||||||
| Female | 146 | 4.9 | 24 | 2.3 | 21 | 4.4 | 80 | 9.0 | 1 | 1.1 | 4 | 4.7 | 3 | 1.9 | 2 | 2.7 | 11 | 5.8 | < 0.001 |
| Male | 2864 | 95.1 | 1026 | 97.7 | 461 | 95.6 | 804 | 91.0 | 86 | 98.9 | 81 | 95.3 | 155 | 98.1 | 71 | 97.3 | 180 | 94.2 | |
| Age | |||||||||||||||||||
| ≤ 40 | 201 | 6.7 | 73 | 7.0 | 13 | 2.7 | 95 | 10.7 | 0 | 0.0 | 3 | 3.5 | 12 | 7.6 | 0 | 0.0 | 5 | 2.6 | < 0.001 |
| 41–50 | 677 | 22.5 | 232 | 22.1 | 89 | 18.5 | 229 | 25.9 | 10 | 11.5 | 26 | 30.6 | 43 | 27.2 | 13 | 17.8 | 35 | 18.3 | |
| 51–60 | 1067 | 35.4 | 394 | 37.5 | 171 | 35.5 | 285 | 32.2 | 41 | 47.1 | 34 | 40.0 | 58 | 36.7 | 24 | 32.9 | 60 | 31.4 | |
| 61–70 | 684 | 22.7 | 227 | 21.6 | 131 | 27.2 | 181 | 20.5 | 25 | 28.7 | 18 | 21.2 | 26 | 16.5 | 25 | 34.2 | 51 | 26.7 | |
| ≥ 71 | 381 | 12.7 | 124 | 11.8 | 78 | 16.2 | 94 | 10.6 | 11 | 12.6 | 4 | 4.7 | 19 | 12.0 | 11 | 15.1 | 40 | 20.9 | |
| Smoking | |||||||||||||||||||
| No | 589 | 19.6 | 199 | 19.0 | 86 | 17.8 | 184 | 20.8 | 18 | 20.7 | 12 | 14.1 | 25 | 15.8 | 14 | 19.2 | 51 | 26.7 | 0.126 |
| Yes | 2421 | 80.4 | 851 | 81.0 | 396 | 82.2 | 700 | 79.2 | 69 | 79.3 | 73 | 85.9 | 133 | 84.2 | 59 | 80.8 | 140 | 73.3 | |
| Betel nut | |||||||||||||||||||
| No | 970 | 32.2 | 335 | 31.9 | 142 | 29.5 | 307 | 34.7 | 29 | 33.3 | 23 | 27.1 | 41 | 25.9 | 22 | 30.1 | 71 | 37.2 | 0.162 |
| Yes | 2040 | 67.8 | 715 | 68.1 | 340 | 70.5 | 577 | 65.3 | 58 | 66.7 | 62 | 72.9 | 117 | 74.1 | 51 | 69.9 | 120 | 62.8 | |
| Alcohol | |||||||||||||||||||
| No | 1014 | 33.7 | 367 | 35.0 | 175 | 36.3 | 285 | 32.2 | 28 | 32.2 | 18 | 21.2 | 40 | 25.3 | 26 | 35.6 | 75 | 39.3 | 0.018 |
| Yes | 1996 | 66.3 | 683 | 65.0 | 307 | 63.7 | 599 | 67.8 | 59 | 67.8 | 67 | 78.8 | 118 | 74.7 | 47 | 64.4 | 116 | 60.7 | |
| T stage | |||||||||||||||||||
| 1 | 1320 | 43.9 | 487 | 46.4 | 136 | 28.2 | 398 | 45.0 | 39 | 44.8 | 47 | 55.3 | 47 | 29.7 | 45 | 61.6 | 121 | 63.4 | < 0.001 |
| 2 | 722 | 24.0 | 282 | 26.9 | 66 | 13.7 | 233 | 26.4 | 16 | 18.4 | 21 | 24.7 | 35 | 22.2 | 19 | 26.0 | 50 | 26.2 | |
| 3 | 173 | 5.7 | 78 | 7.4 | 8 | 1.7 | 60 | 6.8 | 6 | 6.9 | 1 | 1.2 | 7 | 4.4 | 4 | 5.5 | 9 | 4.7 | |
| 4 | 795 | 26.4 | 203 | 19.3 | 272 | 56.4 | 193 | 21.8 | 26 | 29.9 | 16 | 18.8 | 69 | 43.7 | 5 | 6.8 | 11 | 5.8 | |
| N stage | |||||||||||||||||||
| Without ND | 664 | 22.1 | 228 | 21.7 | 118 | 24.5 | 154 | 17.4 | 31 | 35.6 | 13 | 15.3 | 30 | 19.0 | 19 | 26.0 | 71 | 37.2 | < 0.001 |
| 0 | 1700 | 56.5 | 605 | 57.6 | 271 | 56.2 | 491 | 55.5 | 42 | 48.3 | 55 | 64.7 | 91 | 57.6 | 45 | 61.6 | 100 | 52.4 | |
| 1 | 223 | 7.4 | 86 | 8.2 | 24 | 5.0 | 77 | 8.7 | 7 | 8.0 | 5 | 5.9 | 9 | 5.7 | 3 | 4.1 | 12 | 6.3 | |
| 2 | 394 | 13.1 | 121 | 11.5 | 64 | 13.3 | 150 | 17.0 | 7 | 8.0 | 11 | 12.9 | 27 | 17.1 | 6 | 8.2 | 8 | 4.2 | |
| 3 | 29 | 1.0 | 10 | 1.0 | 5 | 1.0 | 12 | 1.4 | 0 | 0.0 | 1 | 1.2 | 1 | 0.6 | 0 | 0.0 | 0 | 0.0 | |
| Overall stage | |||||||||||||||||||
| Early | 1766 | 58.7 | 660 | 62.9 | 187 | 38.8 | 530 | 60.0 | 49 | 56.3 | 59 | 69.4 | 66 | 41.8 | 59 | 80.8 | 156 | 81.7 | < 0.001 |
| Advance | 1244 | 41.3 | 390 | 37.1 | 295 | 61.2 | 354 | 40.0 | 38 | 43.7 | 26 | 30.6 | 92 | 58.2 | 14 | 19.2 | 35 | 18.3 | |
| ECS | |||||||||||||||||||
| Without ND | 664 | 22.1 | 228 | 21.7 | 118 | 24.5 | 154 | 17.4 | 31 | 35.6 | 13 | 15.3 | 30 | 19.0 | 19 | 26.0 | 71 | 37.2 | < 0.001 |
| No | 2113 | 70.2 | 739 | 70.4 | 334 | 69.3 | 648 | 73.3 | 51 | 58.6 | 63 | 74.1 | 115 | 72.8 | 50 | 68.5 | 113 | 59.2 | |
| Yes | 233 | 7.7 | 83 | 7.9 | 30 | 6.2 | 82 | 9.3 | 5 | 5.7 | 9 | 10.6 | 13 | 8.2 | 4 | 5.5 | 7 | 3.7 | |
| Neck LV IV and V metastasis | |||||||||||||||||||
| No | 2937 | 97.6 | 1030 | 98.1 | 473 | 98.1 | 854 | 96.6 | 84 | 96.6 | 83 | 97.6 | 151 | 95.6 | 72 | 98.6 | 190 | 99.5 | 0.112 |
| Yes | 73 | 2.4 | 20 | 1.9 | 9 | 1.9 | 30 | 3.4 | 3 | 3.4 | 2 | 2.4 | 7 | 4.4 | 1 | 1.4 | 1 | 0.5 | |
| Skip metastasis | |||||||||||||||||||
| No | 2957 | 98.2 | 1040 | 99.0 | 478 | 99.2 | 852 | 96.4 | 86 | 98.9 | 83 | 97.6 | 154 | 97.5 | 73 | 100.0 | 191 | 100.0 | < 0.001 |
| Yes | 53 | 1.8 | 10 | 1.0 | 4 | 0.8 | 32 | 3.6 | 1 | 1.1 | 2 | 2.4 | 4 | 2.5 | 0 | 0.0 | 0 | 0.0 | |
| Grade | |||||||||||||||||||
| Well | 514 | 17.5 | 220 | 21.5 | 79 | 16.8 | 113 | 13.3 | 20 | 23.3 | 4 | 4.8 | 18 | 11.9 | 15 | 20.5 | 45 | 23.9 | < 0.001 |
| Moderately | 2269 | 77.5 | 765 | 74.6 | 371 | 78.9 | 683 | 80.2 | 62 | 72.1 | 74 | 88.1 | 125 | 82.8 | 56 | 76.7 | 133 | 70.7 | |
| Poorly | 146 | 5.0 | 40 | 3.9 | 20 | 4.3 | 56 | 6.6 | 4 | 4.7 | 6 | 7.1 | 8 | 5.3 | 2 | 2.7 | 10 | 5.3 | |
| Reccur | |||||||||||||||||||
| No | 2353 | 78.2 | 829 | 79.0 | 374 | 77.6 | 676 | 76.5 | 69 | 79.3 | 69 | 81.2 | 112 | 70.9 | 63 | 86.3 | 161 | 84.3 | 0.044 |
| Yes | 657 | 21.8 | 221 | 21.0 | 108 | 22.4 | 208 | 23.5 | 18 | 20.7 | 16 | 18.8 | 46 | 29.1 | 10 | 13.7 | 30 | 15.7 | |
| Death | |||||||||||||||||||
| No | 1781 | 59.2 | 682 | 65.0 | 249 | 51.7 | 513 | 58.0 | 34 | 39.1 | 52 | 61.2 | 82 | 51.9 | 52 | 71.2 | 117 | 61.3 | < 0.001 |
| Yes | 1229 | 40.8 | 368 | 35.0 | 233 | 48.3 | 371 | 42.0 | 53 | 60.9 | 33 | 38.8 | 76 | 48.1 | 21 | 28.8 | 74 | 38.7 | |
ND neck dissection, RMT retromolar trigone, ECS extra-nodal spread.