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. 2021 Jul 29;4:927. doi: 10.1038/s42003-021-02444-z

Fig. 7. Comparison of an hArg1 loop when bound to mAb5, mAb1 and small molecule-bound hArg1.

Fig. 7

An overlay of the hArg1 loop containing residues Lys16-Val24 is shown in Fig. 5d. When bound to the mAb5 antibody, the positioning of this loop (cyan) is altered when compared to hArg1 bound to mAb1 (green) or hArg1 bound to a small molecule (orange). a A closeup of Arg21 in all three structures highlights the difference in orientation of Arg21 which moves outward by 5.8–6.4 Å. b Arg21 interacts with Asp30 of the mAb5 heavy chain, which sits ~2.2–3.5 Å away.