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. 2021 Jul 29;11:15410. doi: 10.1038/s41598-021-94514-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Venn diagraph depicting the overlap in upregulated (a) or downregulated (b) genes in BT-549 and MDA-MB-231 under the indicated experimental conditions. Upregulated genes are defined as the genes upregulated (FC ≥ 2.0) by TGFB and those were downregulated (FC ≤ 2.0) by SBSB431542. Downregulated genes were defined as the genes downregulated by TGFB1 (FC ≤ 2.0) and those were induced by SB431542 (FC ≥ 2.0). (c) Heatmap depicting commonly altered (up and down) protein coding genes under different experimental conditions.