Fig. 3.

RBCs have GPx4 and its abundance varies across RBC donors and correlates with select RBC molecules.

(A) Relative abundance of GPx4 protein in RBCs at “day 0” of cold storage across the individual donors in the twin study. Proteomics data from Ref. [4].

(B) Rank order plot of RBC molecules correlated or anti-correlated with GPx4, highlighting select lipid-anchored proteins correlated with GPx4 (red), complement proteins anti-correlated with GPx4 (purple), and lysophospholipids anti-correlated with GPx4 (blue). Proteomics and metabolomics data from Ref. [4]. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)