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Performance comparison of 13 non-linear optimization solvers. Following the preparation of 100 initial metabolic flux vectors, each metabolic flux vector was optimized for 60 s using a non-linear optimization solver. Median RSSs of 100 metabolic flux vectors are shown in the figure. (a) Comparison using a13C-MFA dataset of E. coli (Okahashi et al., 2017). (b) Comparison using a13C-MFA dataset of cancer cells (Araki et al., 2018).
