Table 3.
Clinical and pathologic characteristics of HCC patients and prognostic analysis.
| Variables | Count of events/total (n = 370) | MST (days) | HR (95% CI) | P value |
| Age (yr) | 70/232 | 2456 | 1 | .160 |
| ≤65 | 56/138 | 1490 | 1.288 (0.904-1.834) | |
| >65 | ||||
| Gender | 48/121 | 1560 | 1 | .362 |
| Female | 78/249 | 2486 | 0.845 (0.588–1.214) | |
| Male | ||||
| Serum AFP (ng/mL)∗ | 60/213 | 2456 | 1 | .852 |
| ≤400 | 21/64 | 2486 | 1.049 (0.633–1.738) | |
| >400 | ||||
| Child-Pugh grade† | 57/216 | 2542 | 1 | .077 |
| A | 9/22 | 1005 | 1.872 (0.924–3.795) | |
| B / C | ||||
| Ishak fibrosis score‡ | 29/74 | 2456 | 1 | .847 |
| 0 | 7/31 | 1791 | 0.757 (0.325–1.762) | |
| 1 / 2 | 6/28 | NA | 0.686 (0.281–1.675) | |
| 3 / 4 | 2/9 | 1386 | 0.720 (0.170–3.056) | |
| 5 | 17/69 | NA | 0.750 (0.408–1.380) | |
| 6 | ||||
| Tumor stage§ | 41/171 | 2532 | 1 | <.001 |
| I | 25/85 | 1852 | 1.436 (0.871–2.369) | |
| II | 47/90 | 770 | 2.751 (1.803–4.198) | |
| III / IV | ||||
| Histologic grade|| | 18/55 | 2116 | 1 | .786 |
| G1 | 58/177 | 1685 | 1.148 (0.676–1.950) | |
| G2 | 41/121 | 1622 | 1.180 (0.676–2.060) | |
| G3 | 5/12 | NA | 1.825 (0.648–5.140) | |
| G4 | ||||
| MVI¶ | 59/206 | 2131 | 1 | .185 |
| No | 34/108 | 2486 | 1.331 (0.870–2.034) | |
| Yes | ||||
| Radical resection# | 106/323 | 2116 | 1 | .003 |
| R0 | 17/40 | 837 | 2.137 (1.276–3.581) | |
| R1 / R2 / RX | ||||
| Risk index | 46/185 | 3125 | 1 | <.001 |
| Low | 80/185 | 1005 | 2.400 (1.667–3.454) | |
| High |