Table 6.
All significantly enriched KEGG signaling pathways of common differentially expressed mRNAs between MF vs. AMI and HF vs. MF.
| ID | Description | mRNA ID | Count | P-value |
|---|---|---|---|---|
| hsa04640 | Hematopoietic cell lineage | HLA-DPB1/IL5RA/CR1/IL4R/IL1R2/ITGAM/CSF3R/HLA-DPA1/FLT3/IL1R1 | 10 | 2.08E-05 |
| hsa05202 | Transcriptional misregulation in cancer | RARA/CEBPB/IGF1R/SPI1/CXCL8/MLLT1/FLT3/DEFA3/ITGAM/RXRA/MMP9/BCL6/IL1R2 | 13 | 8.58E-05 |
| hsa05140 | Leishmaniasis | HLA-DPB1/NCF1/CR1/NCF4/TLR2/ITGAM/MAPK13/HLA-DPA1 | 8 | 9.82E-05 |
| hsa05152 | Tuberculosis | CEBPB/CR1/HLA-DPB1/PLK3/MAPK13/CTSD/TCIRG1/ITGAM/NOD2/HLA-DPA1/TLR2/LSP1 | 12 | 0.000236 |
| hsa04659 | Th17 cell differentiation | RARA/HLA-DPB1/IL4R/RXRA/STAT5A/JAK3/MAPK13/HLA-DPA1/IL1R1 | 9 | 0.000283 |
| hsa04658 | Th1 and Th2 cell differentiation | HLA-DPB1/MAML3/NOTCH1/STAT5A/JAK3/MAPK13/HLA-DPA1/IL4R | 8 | 0.000491 |
| hsa05134 | Legionellosis | CR1/HSPA6/CXCL8/TLR2/HSPA1B/ITGAM | 6 | 0.000757 |
| hsa04380 | Osteoclast differentiation | NCF1/SPI1/SOCS3/SIRPA/NCF4/JUNB/MAPK13/LILRA5/IL1R1 | 9 | 0.000991 |
| hsa04668 | TNF signaling pathway | CEBPB/SOCS3/JUNB/IL18R1/MAPK13/CFLAR/NOD2/MMP9 | 8 | 0.001591 |
| hsa04670 | Leukocyte transendothelial migration | NCF1/NCF4/MAPK13/RASSF5/ACTN1/PXN/MMP9/ITGAM | 8 | 0.001785 |
| hsa05321 | Inflammatory bowel disease (IBD) | HLA-DPB1/IL4R/IL18R1/TLR2/NOD2/HLA-DPA1 | 6 | 0.001829 |
| hsa04930 | Type II diabetes mellitus | HK3/PRKCZ/IRS2/CACNA1E/SOCS3 | 5 | 0.00213 |
| hsa05144 | Malaria | KLRK1/TLR2/CR1/KLRB1/CXCL8 | 5 | 0.002823 |
| hsa00052 | Galactose metabolism | HK3/MGAM/MGAM2/GAA | 4 | 0.003178 |
| hsa05200 | Pathways in cancer | ADCY4/CSF2RB/IGF1R/SPI1/CSF3R/ARHGEF11/IL5RA/CXCL8/RASSF5/NOTCH1/RARA/GNB2/STAT5A/GLI1/RALB/JAK3/RXRA/MMP9/FLT3/IL4R | 20 | 0.004359 |
| hsa05166 | Human T-cell leukemia virus 1 infection | ADCY4/HLA-DPB1/SPI1/ZFP36/TLN1/ETS2/STAT5A/JAK3/HLA-DPA1/IL1R2/IL1R1 | 11 | 0.00451 |
| hsa04062 | Chemokine signaling pathway | ADCY4/NCF1/PREX1/GRK6/CXCL8/GNB2/PRKCZ/JAK3/WAS/PXN | 10 | 0.004638 |
| hsa05150 | Staphylococcus aureus infection | FCAR/HLA-DPA1/FPR2/ITGAM/HLA-DPB1 | 5 | 0.004676 |
| hsa00500 | Starch and sucrose metabolism | HK3/MGAM/MGAM2/GAA | 4 | 0.005505 |
| hsa05145 | Toxoplasmosis | HLA-DPB1/HSPA6/ALOX5/TLR2/HSPA1B/MAPK13/HLA-DPA1 | 7 | 0.007426 |
| hsa04213 | Longevity regulating pathway - multiple species | ADCY4/HSPA1B/IGF1R/HSPA6/IRS2 | 5 | 0.007775 |
| hsa05131 | Shigellosis | CXCL8/NOD2/WAS/ARPC5/MAPK13 | 5 | 0.009459 |
| hsa04144 | Endocytosis | SMAP2/HSPA6/ARAP1/GRK6/IGF1R/ARPC5/HSPA1B/PRKCZ/IQSEC1/WAS/FOLR3 | 11 | 0.009876 |
| hsa05221 | Acute myeloid leukemia | RARA/STAT5A/SPI1/FLT3/ITGAM | 5 | 0.010073 |
| hsa04145 | Phagosome | FCAR/HLA-DPB1/NCF1/NCF4/TCIRG1/TLR2/ITGAM/HLA-DPA1 | 8 | 0.010779 |
| hsa05146 | Amoebiasis | ACTN1/CXCL8/TLR2/ITGAM/IL1R2/IL1R1 | 6 | 0.011757 |
| hsa04140 | Autophagy - animal | IGF1R/ULK1/WIPI2/RRAS2/CTSD/IRS2/CFLAR | 7 | 0.014168 |
| hsa04630 | JAK-STAT signaling pathway | CSF2RB/IL5RA/IL4R/SOCS3/STAT5A/OSM/JAK3/CSF3R | 8 | 0.015934 |
| hsa04913 | Ovarian steroidogenesis | ADCY4/IGF1R/ALOX5/HSD17B2 | 4 | 0.016201 |
| hsa04915 | Estrogen signaling pathway | ADCY4/RARA/HSPA6/HSPA1B/CTSD/FKBP5/MMP9 | 7 | 0.019162 |
| hsa05418 | Fluid shear stress and atherosclerosis | NCF1/MAPK13/PRKCZ/MMP9/THBD/IL1R2/IL1R1 | 7 | 0.021319 |
| hsa05164 | Influenza A | HLA-DPB1/HSPA6/SOCS3/CXCL8/HSPA1B/MAPK13/HLA-DPA1/FURIN | 8 | 0.02132 |
| hsa04015 | Rap1 signaling pathway | ADCY4/IGF1R/RASSF5/TLN1/PRKCZ/ITGAM/MAPK13/SIPA1L2/RALB | 9 | 0.022435 |
| hsa04360 | Axon guidance | EPHB4/NTNG2/LRRC4/PLXNA2/UNC5A/PRKCZ/FES/SEMA4B | 8 | 0.024087 |
| hsa04810 | Regulation of actin cytoskeleton | ACTN1/RRAS2/FGD3/ITGB8/MYH9/ARPC5/ITGAM/WAS/PXN | 9 | 0.02709 |
| hsa00051 | Fructose and mannose metabolism | HK3/PFKFB3/PFKFB4 | 3 | 0.027507 |
| hsa05132 | Salmonella infection | CXCL8/MYH9/WAS/ARPC5/MAPK13 | 5 | 0.028571 |
| hsa05323 | Rheumatoid arthritis | HLA-DPA1/HLA-DPB1/TLR2/TCIRG1/CXCL8 | 5 | 0.032478 |
| hsa04060 | Cytokine-cytokine receptor interaction | CSF2RB/IL5RA/IL4R/CXCL8/IL18R1/TNFRSF10C/OSM/IL17RA/CSF3R/IL1R2/IL1R1 | 11 | 0.033849 |
| hsa04657 | IL-17 signaling pathway | CEBPB/CXCL8/MAPK13/IL17RA/MMP9 | 5 | 0.038184 |
| hsa05223 | Non-small cell lung cancer | STAT5A/RASSF5/JAK3/RXRA | 4 | 0.042512 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | CXCL8/STAT5A/PRKCZ/THBD/MAPK13 | 5 | 0.047826 |
| hsa05322 | Systemic lupus erythematosus | HLA-DPB1/ACTN1/HIST1H2BE/HLA-DPA1/HIST1H2AD/TROVE2 | 6 | 0.048665 |
| hsa04920 | Adipocytokine signaling pathway | ACSL1/IRS2/RXRA/SOCS3 | 4 | 0.048728 |
| hsa04066 | HIF-1 signaling pathway | HK3/PFKFB3/MKNK1/IGF1R/TIMP1 | 5 | 0.049561 |