Table 4.

Pairwise comparison results from network meta-analysis on cardiovascular death.

Albiglutide

0.9 (0.67–1.2)

1.05 (0.78–1.42)

0.98 (0.73–1.3)

0.67 (0.48–0.93)

0.99 (0.73–1.34)

0.95 (0.71–1.26)

0.84 (0.62–1.13)

1.05 (0.76–1.47)

0.53 (0.27–1.02)

1.08 (0.84–1.37)

0.95 (0.7–1.29)

1.05 (0.65–1.71)

1.11 (0.84–1.48)

Canagliflozin

1.17 (0.93–1.48)

1.09 (0.88–1.35)

0.74 (0.57–0.98)

1.1 (0.87–1.4)

1.05 (0.85–1.3)

0.93 (0.74–1.17)

1.17 (0.89–1.54)

0.59 (0.31–1.1)

1.2 (1.03–1.4)

1.06 (0.83–1.35)

1.17 (0.75–1.82)

0.95 (0.7–1.28)

0.85 (0.67–1.08)

Dapagliflozin

0.93 (0.74–1.17)

0.63 (0.47–0.84)

0.94 (0.73–1.21)

0.9 (0.71–1.13)

0.8 (0.62–1.02)

1 (0.75–1.33)

0.5 (0.26–0.94)

1.02 (0.85–1.22)

0.9 (0.7–1.17)

1 (0.64–1.57)

1.02 (0.77–1.36)

0.92 (0.74–1.14)

1.08 (0.85–1.36)

Dulaglutide

0.68 (0.52–0.9)

1.01 (0.8–1.28)

0.97 (0.78–1.2)

0.86 (0.68–1.08)

1.08 (0.82–1.41)

0.54 (0.29–1.01)

1.1 (0.94–1.28)

0.97 (0.77–1.24)

1.08 (0.69–1.67)

1.5 (1.07–2.09)

1.35 (1.02–1.76)

1.58 (1.18–2.11)

1.47 (1.12–1.93)

Empagliflozin

1.48 (1.11–1.99)

1.42 (1.08–1.86)

1.26 (0.95–1.67)

1.58 (1.15–2.17)

0.79 (0.41–1.51)

1.61 (1.28–2.02)

1.43 (1.07–1.91)

1.58 (0.99–2.53)

1.01 (0.75–1.37)

0.91 (0.72–1.15)

1.06 (0.83–1.37)

0.99 (0.78–1.26)

0.67 (0.5–0.9)

Ertugliflozin

0.96 (0.76–1.21)

0.85 (0.66–1.09)

1.06 (0.8–1.42)

0.53 (0.28–1)

1.09 (0.91–1.31)

0.96 (0.74–1.25)

1.07 (0.68–1.67)

1.06 (0.79–1.41)

0.95 (0.77–1.17)

1.11 (0.88–1.4)

1.03 (0.84–1.28)

0.71 (0.54–0.92)

1.05 (0.83–1.32)

Exenatide

0.89 (0.71–1.11)

1.11 (0.85–1.46)

0.56 (0.3–1.04)

1.14 (0.98–1.32)

1.01 (0.79–1.27)

1.11 (0.72–1.72)

1.19 (0.88–1.61)

1.07 (0.85–1.35)

1.26 (0.98–1.61)

1.17 (0.93–1.47)

0.8 (0.6–1.06)

1.18 (0.92–1.52)

1.13 (0.9–1.41)

Liraglutide

1.26 (0.95–1.66)

0.63 (0.33–1.18)

1.28 (1.08–1.52)

1.13 (0.88–1.46)

1.26 (0.8, 1.97)

0.95 (0.68–1.32)

0.85 (0.65–1.12)

1 (0.75–1.33)

0.93 (0.71–1.22)

0.63 (0.46–0.87)

0.94 (0.7–1.25)

0.9 (0.69–1.17)

0.8 (0.6–1.06)

Lixisenatide

0.5 (0.26–0.96)

1.02 (0.82–1.28)

0.9 (0.68–1.21)

1 (0.63–1.59)

1.9 (0.98–3.67)

1.7 (0.91–3.21)

2 (1.06–3.8)

1.86 (0.99–3.51)

1.27 (0.66–2.44)

1.88 (1–3.56)

1.79 (0.96–3.38)

1.59 (0.85–3.01)

2 (1.04–3.84)

Osemaglutide

2.04 (1.11–3.77)

1.8 (0.96–3.42)

2 (0.96–4.22)

0.93 (0.73–1.19)

0.83 (0.72–0.97)

0.98 (0.82–1.17)

0.91 (0.78–1.06)

0.62 (0.5–0.78)

0.92 (0.77–1.1)

0.88 (0.76–1.02)

0.78 (0.66–0.92)

0.98 (0.78–1.22)

0.49 (0.26–0.9)

Placebo

0.89 (0.73–1.07)

0.98 (0.65–1.48)

1.05 (0.78–1.43)

0.94 (0.74–1.2)

1.11 (0.86–1.43)

1.03 (0.81–1.31)

0.7 (0.52–0.94)

1.04 (0.8–1.35)

0.99 (0.78–1.26)

0.88 (0.68–1.13)

1.11 (0.83–1.48)

0.55 (0.29–1.05)

1.13 (0.94–1.36)

Sotagliflozin

1.11 (0.7–1.74)

0.95 (0.59–1.53)

0.85 (0.55–1.33)

1 (0.64–1.56)

0.93 (0.6–1.44)

0.63 (0.4–1.01)

0.94 (0.6–1.47)

0.9 (0.58–1.39)

0.79 (0.51–1.24)

1 (0.63–1.59)

0.5 (0.24–1.04)

1.02 (0.68–1.54)

0.9 (0.58–1.42)

Ssemaglutide