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. 2021 Jul 16;12:708645. doi: 10.3389/fphar.2021.708645

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Copyright © 2021 Wang, Wang, Cao, Dong and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Timeline of experimental design. The mice were divided into control group (CON), sleep deprivation group (SD), SD + low melatonin (20 mg/kg) supplement group (SD + L-Mel), SD + high melatonin (40 mg/kg) supplement group (SD + H-Mel), melatonin (20 mg/kg) supplement group (Mel) and SD + Fer-1 (1 mg/kg) supplement group (SD + Fer-1). The asterisk represents mice that were subjected to 72 h acute sleep deprivation and received treatment with or without Mel or Fer-1 supplementation.