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. 2021 Jul 16;12:708645. doi: 10.3389/fphar.2021.708645

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Copyright © 2021 Wang, Wang, Cao, Dong and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of melatonin on MT2/ERK/Nrf2 signaling in the hippocampus of sleep-deprived mice (A, C) Immunohistochemical staining of MT2 in hippocampus. Brown indicates positive cells. (B, D) negative control. A–B: bar = 200 μm; C–D: bar = 50 μm. (E–H) Relative protein levels of MT1, MT2, p-ERK1/2 and Nrf2 were normalized to β-actin (n = 6). Differences were assessed using one-way ANOVA. The result represents the mean ± standard error of the mean. Values not sharing a common superscript letter differ significantly at p < 0.05; those with the same letter do not differ significantly (p ≥ 0.05). CON: control group, SD: sleep deprivation group, SD + L-Mel: SD + low melatonin (20 mg/kg) supplement group, SD + H-Mel: SD + high melatonin (40 mg/kg) supplement group.