TABLE 2.

The 16 typical examples of multi-target compounds.

Compound name	Chemical structure	Predicted targets
L-Arctigenin		ALOX12, ACHE, PTGS2, ESR1, GABRG1, GSK3B, PDE4A, TNF
Dihydrocapsaicin		ALOX12, ACHE, PTGS2, ESR1
Rhapontigenin		ALOX12, ACHE, APP, PTGS2, ESR1, GSK3B, NOS2, MAOB, MAPT, TNF
6-Shogaol		ALOX12, ACHE, PTGS2, MAOB
6-Gingerol		ALOX12, ACHE, PTGS2, TNF
10-Gingerol		ALOX12, ACHE, PTGS2, TNF
Isorhapontigenin		ALOX12, ACHE, APP, PTGS2, ESR1, GSK3B, MAOB, MAPT, TNF
Nonivamide		ALOX12, ACHE, PTGS2, ESR1, MAOB
Flavokawain B		ALOX12, ACHE, APP, PTGS2, ESR1, GABRG1, GSK3B, NOS2, MAOB, MAPT, TNF
Demethoxycurcumin		ALOX12, ACHE, APP, PTGS2, GSK3B, MAOB, MAPT
Bisdemethoxycurcumin		ALOX12, ACHE, APP, PTGS2, GSK3B, MAOB
Carnosol		PTGS2, ESR1, TNF
Cardamonin		ALOX12, ACHE, APP, PTGS2, ESR1, GABRG1, GSK3B, NOS2, MAOB, MAPT, TNF
Matairesinol		ALOX12, ACHE, BACE1, PTGS2, ESR1, GABRG1, GSK3B, PDE4A, TNF
Bavachromene		ACHE, APP, PTGS2
3,4-Dimethoxycinnamic acid		ACHE, APP, PTGS2, GSK3B