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Simplified metabolism of thiopurines. XO, xanthine oxidase; TPMT, thiopurine methyltransferase; HPRT, hypoxanthine-guanine phosphoribosyltransferase; 5-IMPDH, 5- inosine monophosphate dehydrogenase; TIMP, thiosine monophosphate; TGNs, thioguanine nucleotides; TGMP, thioguanine monophosphate; TGDP, thioguanine diphosphate; TGTP, thioguanine triphosphate.
