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. 2021 Jul 16;9:702890. doi: 10.3389/fcell.2021.702890

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Copyright © 2021 Wang, Zhang, Liu, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In colitis-induced liver injury, neutrophils are activated in the liver. The activation status of neutrophils was evaluated via neutrophil-derived reactive oxygen species (ROS), neutrophil-derived cytokines, and phosphorylation of p38. (A) Neutrophil-derived ROS in the peripheral blood (PB), portal vein (PV), and liver were tested via flow cytometry in the following seven groups: normal control (NC), acute dextran sulfate sodium colitis (aDSS), sinusoidal obstruction syndrome (SOS), lipopolysaccharide-induced pneumonia (LPSPn), SOS + LPSPn, DSS + SOS, and DSS + SOS + LPSPn. (B) Neutrophil-derived cytokines in the peripheral blood, portal vein, and the liver were evaluated in NC, aDSS, SOS, and DSS + SOS groups. (C) The phosphorylation of neutrophil p38 was also tested in the peripheral blood, portal vein, and liver. Asterisk indicates that the level is significantly different with normal control. *p < 0.05; ***p < 0.001 by t-test; n = 5–6 per group; panels A and B are representative of three experiments; panel C is representative of two experiments.