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. 2021 Jul 16;8:701612. doi: 10.3389/fvets.2021.701612

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Copyright © 2021 Wang, Qin, Zhao, Yuan, Yang, Mi, Zhao, Lu, Lu, Chen, He, Yang, Yi, Wu, Chen, Wei, Huang and Ouyang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diarrhea scores, fecal viral shedding, virus distribution and the VH:CD ratios in piglets infected with the PDCoV CHN/GX/1468B/2017 strain. (A) Diarrhea scores of 7-day-old piglets challenged with the PDCoV CHN/GX/1468B/2017 strain. Clinical symptoms were monitored daily, and the severity of diarrhea for each piglet was scored using the following criteria: 0 = normal, 1 = fecal deformity, 2 = mild diarrhea, and 3 = watery diarrhea. (B) Fecal viral shedding in 7-day-old piglets challenged with the PDCoV CHN/GX/1468B/2017 strain. PDCoV RNA shedding in the feces was quantitated daily from the four challenged piglets. (C) Virus distribution in 7-day-old piglets challenged with the PDCoV CHN/GX/1468B/2017 strain. PDCoV RNA loads in tissues collected at 7 DPI were measured by using qRT-PCR. (D) The ratio of villous height to crypt depth (VH:CD) in small intestines from piglets inoculated with the PDCoV CHN/GX/1468B/2017 strain. Each point/bar represents the average values of four piglets, the numbers above the bar in graphs (B,C) represent the ratio of PDCoV positive piglets to the total in each group, and the asterisk indicates a statistically significant difference between the negative control and CHN/GX/1468B/2017 groups (***p < 0.001).