Table 3.
Univariate and multivariate analyses of prognostic factors of combined hepatocellular carcinoma and cholangiocarcinoma patients undergoing surgery.
| Variables | Category | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Year of diagnosis | 2004-2009 */2010-2015 | 1.02 | 0.69-1.51 | 0.93 | |||
| Gender | Male*/Female | 1.11 | 0.73-1.69 | 0.64 | |||
| Ethnicity | Caucasian*/African–American/Others | 1.00 | 0.78-1.30 | 0.99 | |||
| Age at diagnosis | ≤60*/>60 | 1.09 | 0.85-1.40 | 0.50 | |||
| Marital status | Married*/Single/(Divorced/separated)/Widowed | 1.17 | 0.89-1.55 | 0.27 | |||
| Tumor size | ≤ 5 cm*/>5 cm | 2.24 | 1.49-3.37 | <0.01 | 1.52 | 0.96-2.40 | 0.07 |
| Grade | I*/II/III/IV | 1.53 | 1.14-2.06 | <0.01 | 1.35 | 0.98-1.86 | 0.07 |
| TNM stage | I*/II/III/IV/Unknown stage | 1.46 | 1.21-1.78 | <0.01 | 1.22 | 1.01-1.48 | 0.04 |
| T stage | T1*/T2/T3/T4/TX | 1.41 | 1.17-1.70 | <0.01 | 1.02 | 0.82-1.28 | 0.86 |
| N stage | N0*/N1/NX | 2.29 | 1.67-3.16 | <0.01 | 1.32 | 0.83-2.12 | 0.24 |
| M stage | M0*/M1/MX | 2.55 | 1.85-3.51 | <0.01 | 1.83 | 1.12-2.99 | 0.02 |
| Surgery type | Yes*/No surgery | 0.81 | 0.51-1.27 | 0.35 | |||
| Chemotherapy | Yes*/(No/unknown) | 1.59 | 1.07-2.36 | 0.02 | 0.95 | 0.60-1.48 | 0.81 |
| Radiation | Yes*/(No/unknown) | 1.65 | 0.88-3.10 | 0.12 | |||
HR, hazard ratio; CI, confidence interval; *reference category.