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. 2021 Jul 16;9:658115. doi: 10.3389/fcell.2021.658115

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Copyright © 2021 Yu, Lin, Ai, Tan, Huang and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The upregulated level of circ_PVT1 in LC tissues and cells. (A) The differentially expressed circRNAs are shown in LC tumor tissues and adjacent normal tissues. (B) RNA-seq identified differentially expressed circRNAs’ were cross-matched with a microarray generated from four tumor samples and four normal tissues. (C) The expression of circ_PVT1 was detected in LC patients’ tumor tissues and adjacent normal tissues. **P < 0.01, n = 30. (D) The level of circ_PVT1 in LC cells (Me4, TU212, Hep-2), NP69 cells was indicated as control. *P < 0.05, n = 5. (E) The subcellular localization of circ_PVT1 in Hep-2 cells.