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. 2021 Jul 16;9:658115. doi: 10.3389/fcell.2021.658115

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Copyright © 2021 Yu, Lin, Ai, Tan, Huang and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of circ_PVT1 inhibits tumor growth in vivo. (A) The tumor image in Len-sh-circ_NC and Len-sh-circ_circ_PVT1. n = 5. (B,C) The tumor volume and weight were measured in Len-sh-circ_NC and Len-sh-circ_circ_PVT1 group. *P < 0.05. n = 5. (D) H&E staining in tumor tissues. (E) The protein level of p53, p21, and Cyclin D1 was detected in tumor tissues. *P < 0.05, ^∗∗P < 0.01. n = 5. (F) The protein level of DKK1, NKD1, phosphorylation-GSK3β (p-GSK3β), GSK3β, β-catenin, and wnt4 in tumor tissues. *P < 0.05, n = 4. (G) Model patterns of circ_PVT1/miR-21-5p/CBX4 axis.