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. 2021 Jul 16;11:698551. doi: 10.3389/fonc.2021.698551

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Copyright © 2021 Kong, Liu, Tan, Tai, Phua, Poh, Yeo, Chua, Haw, Ling, Ng, Tan, Loh, Tan, Ng, Ang, Toh, Lee, Lim, Lim, Hillmer, Yap and Lim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genomics alteration detected in the breast cancer samples. The rectangle panels and colors are as described in Figure 2 . In addition, the time point of the serially collected samples for selected patients are represented by the different tones of green color at the bottom panel from 1^st (T1) up to 4^th time point (T4) during the course of this study. T0 indicates the time point that the tumor was collected before this study.