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. 2021 Jul 16;9:695544. doi: 10.3389/fcell.2021.695544

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Copyright © 2021 Gao, Dong, Xie and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic alteration and methylation of MUC4 across different cancer types. (A) Alteration frequency of MUC4 across different cancer types in cBioPortal. (B) The prognostic value of MUC4 alteration in LUSC and UCEC. (C) MUC4 promoter methylation level in tumor and normal samples of the TCGA database in UALCAN. The beta value indicates level of DNA methylation ranging from 0 (unmethylated) to 1 (fully methylated). Different beta value cutoffs have been considered to indicate hyper-methylation [beta value: 0.7–0.5] or hypo-methylation [beta-value: 0.3–0.25].