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. 2021 Jul 16;11:661184. doi: 10.3389/fonc.2021.661184

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Copyright © 2021 Zhu, Li, Wang, Zhou, Fan, Ma, Gao, Gai and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Pinocembrin (PCB) on proteins involved in the cell cycle and apoptosis of breast cancer cells. MCF-7 and MDA-MB-231 cells were incubated with 0, 80, 160, or 240 μM PCB for 72 h. (A) Expression of cyclinB1, Cdc2, cyclinA2, cyclinE1, and cyclinD1 were examined after PCB treatment for 72 h. (B) Expression of Bax, Bcl-2, PARP1, cleaved PARP1, caspase 3, cleaved caspase 3, caspase 9, cleaved caspase 9, and survivin were examined after PCB treatment for 72 h. GAPDH served as an internal control. Bands were quantified using Image J software. Each bar represents the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01 vs. the control group.