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. 2021 Jul 16;12:706757. doi: 10.3389/fimmu.2021.706757

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Copyright © 2021 Gilchuk, Guthals, Bonissone, Shaw, Ilinykh, Huang, Bombardi, Liang, Grinyo, Davidson, Chen, Gunn, Alter, Saphire, Doranz, Bukreyev, Zeitlin, Castellana and Crowe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutralizing potency by class-representative plasma antibodies. Dose-response neutralization of recombinant infectious vesicular stomatitis virus (VSV) expressing EBOV GP in place of the endogenous VSV glycoprotein (VSV/EBOV GP). Curves for intact VSV/EBOV GP neutralization are shown in red, and curves for thermolysin-cleaved VSV/EBOV GP neutralization that generates virus surface-exposed cleaved GP (defined as VSV/EBOV GP_CL) are shown in blue. Half maximal inhibitory concentration (IC₅₀) _was estimated using nonlinear regression analysis. Mean ± SD of technical triplicates from one experiment are shown.