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. 2021 Jul 16;12:702037. doi: 10.3389/fimmu.2021.702037

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Copyright © 2021 Imgenberg-Kreuz, Sandling, Norheim, Johnsen, Omdal, Syvänen, Svenungsson, Rönnblom, Eloranta and Nordmark

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNAm IFN score levels in patients with pSS stratified for lymphoma, discovery and replication cohort together. Dotted red horizontal line indicates threshold for high IFN score. Boxes represent median and interquartile range, whiskers indicate total range. pSS patients without lymphoma indicated in purple in the left panel. In the right panel pSS patients with lymphoma stratified for lymphoma prior to DNA sampling (in red), lymphoma at or after DNA sampling in patients < 70 years of age at lymphoma diagnosis (in dark blue), and lymphoma at or after DNA sampling in patients ≥ 70 years of age at lymphoma diagnosis (in light blue). DNAm IFN score median and interquartile range for each of the pSS subgroups are indicated by filled circles and vertical lines colored according to the corresponding patient subgroup.