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Increased levels of apoptosis and cell cycle arrest. (A and B) Apoptosis rates increased following NRF-1 knockdown in 786-O cells. (C and D) NRF-1 knockdown resulted in G1-phase cell cycle arrest in 786-O cells. Data are presented as the mean ± SEM. n=3. **P<0.01, ***P<0.005. NRF-1, nuclear respiratory factor-1; NC, negative control; shRNA, short hairpin RNA; PI, propidium iodide.
