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. 2021 May 24;11(7):e02195. doi: 10.1002/brb3.2195

FIGURE 6.

FIGURE 6

Reduced seizure‐like EEG by miR‐129–2‐3p Inhibition and counteraction of this effect by silencing of GABRA1. (a‐b) qPCR analysis showing miR‐129–2‐3p (a) and GABRA1 (b) level after treatment of miR‐129–2‐3p antagomir (Anta) with or without GABRA1 siRNA in KA‐induced seizure model (***p <.001 KA +Anta NC compared to Vehicle, ### p <.001 KA+Anta compared to KA +Anta NC, $$$ p <.001 KA +Anta + GABRA1 siRNA compared to KA +Anta, n = 5–10). (c) EEG and representative images for rats treated with miR‐129–2‐3p antagomir (Anta) with or without GABRA1 siRNA in KA‐induced seizure model. (d‐e) Amplitude (d) and spike frequency (e) of seizure EEG were quantified for comparison between different grouops (***p <.001 KA +Anta NC compared to Vehicle, ### p <.001 KA+Anta compared to KA +Anta NC, $$$ p <.001 KA +Anta + GABRA1 siRNA compared to KA +Anta, n = 5–10)