. 2021 Jul 30;10(4):1837–1885. doi: 10.1007/s40121-021-00487-7

Table 2.

Discontinuation of isolation in patients with COVID-19 according to the Italian Ministry of Health

Type of hospitalized patient with COVID-19	Indication for discontinuing isolation
Previously symptomatic patient	The patient can be de-isolated after at least 10 days from the onset of symptoms, provided the patient had a negative molecular test for SARS-CoV-2 performed after at least 10 days from the onset of symptoms and after at least 3 days from disappearance of symptoms (with the exception of anosmia and ageusia/dysgeusia that may last longer)
Previously symptomatic patient with persistent positivity of molecular tests	The patient can be de-isolated after at least 21 days from the onset of symptoms even in the presence of persistent positivity of molecular tests, after at least 7 days from disappearance of symptoms (with the exception of anosmia and ageusia/dysgeusia that may last longer). This criterion may be modulated by health authorities in accordance with experts, with special attention to the immune status of patients (in immunocompromised patients the shedding of viable viral particles may be prolonged)

Type of hospitalized patient with COVID-19

Indication for discontinuing isolation

Previously symptomatic patient

The patient can be de-isolated after at least 10 days from the onset of symptoms, provided the patient had a negative molecular test for SARS-CoV-2 performed after at least 10 days from the onset of symptoms and after at least 3 days from disappearance of symptoms (with the exception of anosmia and ageusia/dysgeusia that may last longer)

Previously symptomatic patient with persistent positivity of molecular tests

The patient can be de-isolated after at least 21 days from the onset of symptoms even in the presence of persistent positivity of molecular tests, after at least 7 days from disappearance of symptoms (with the exception of anosmia and ageusia/dysgeusia that may last longer). This criterion may be modulated by health authorities in accordance with experts, with special attention to the immune status of patients (in immunocompromised patients the shedding of viable viral particles may be prolonged)

Adapted from [279]