Figure 2.

The induced cooperativity spectrum encompasses multiple degrader entities. (A) Theoretical ends of the induced cooperativity spectrum are flanked by molecular glues (left) and bivalent degraders (right). This spectrum can be further dissected into contributions arising from cooperativity (α value) and binary affinity for either POI or E3 Ub ligase recruiter, or a combination thereof. Selected degrader examples are described based on cooperativity values reported or estimated from experimental data from indicated references. (B) Chemical structures for small molecule degraders from part A, with bivalent warheads corresponding to the POI recruiter in teal and E3 ligase in purple.