Figure 5.
Chemoenzymatic sequences to complex molecules. (A) Amino-acid C–H hydroxylation in the synthesis of manzacidin C. (B) Hydroxylative dearomatization in the synthesis of azaphilone natural products. (C) Benzylic hydroxylation en route to xyloketal D synthesis. (D) Alpha deuteration of amino acids in the formation of deutero safinamide.