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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Hepatol. 2021 Feb 18;75(1):163–176. doi: 10.1016/j.jhep.2021.02.004

Figure 3. Il20 deletion selectively enhances the expression of IκBζ-dependent genes including Il6 and Lcn2 in hepatocytes in acute hepatitis.

Figure 3.

I (A-C) WT (n=4–8) and Il20−/− mice (n=4–8) were injected with ConA (12 mg/kg). (A) Western blot analyses of liver IκBζ expression. (B, C) RT-qPCR analyses of liver Nfkbiz mRNA and IκBζ-target genes. (D-F) C57BL/6N mice were injected with Ad-Gfp (n=3 in control group, n=5 in ConA-treated group) and Ad-shNfkbiz (n=3 in control group, n=6 in ConA-treated group) for 7 days, and followed by ConA injection. (D) RT-qPCR analyses of Nfkbiz mRNA. (E) Serum ALT and IL-6 levels were determined. (F) RT-qPCR analyses of liver IκBζ-target genes. Values represent means ± SD. *P< 0.05, **P< 0.01, ***P< 0.001. ConA: Concanavalin A