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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Hepatol. 2021 Feb 18;75(1):163–176. doi: 10.1016/j.jhep.2021.02.004

Figure 4. IL-20 deletion ameliorates bacterial infection by elevating hepatic expression of IκBζ-target antibacterial genes (eg. Il6 and Lcn2).

Figure 4.

(A) C57BL/6N mice (n=6) were infected with K.P. (3000 CFU). Serum IL-20 levels were measured. (B, C) WT (n=19) and Il20−/− mice (n=18) were infected with K.P.. (B) Survival rates were analyzed. *P< 0.05. (C) Blood bacterial load was measured. (D, E) WT (n=4–7) and Il20−/− mice (n=4–8) were infected with K.P.. (D) RT-qPCR analyses of hepatic expression of IκBζ-target genes and other antibacterial genes. P values (Il20−/− versus WT mice at 3-h time point) are indicated. (E) Serum IL-6, LCN2 and IL-22 were measured. (F, G) RT-qPCR analyses of hepatic expression of Il20r mRNAs and representative images of liver IL-20 receptor staining in K.P.-infected mice. Values represent means ± SD. *P< 0.05. K.P.: Klebsiella pneumoniae