Table 2.
Long-term renal outcome in adult IgAV
| References | Patients | Outcome | FU |
|---|---|---|---|
|
Garcia-Porrúa et al. [6] |
31 adults 73 children |
Renal insufficiencya: 10% of adults, 0% of children Persistent haematuria and/or proteinuria without renal insufficiency: 29% of adults, 11% of children |
5–6 years median |
| Blanco et al. [9] |
38 adults 114 children |
Mild renal impairmentb: 11% of adults, 0% of children Microscopic haematuria: 0% of adults, 5% of children |
12–15 months median |
| Coppo et al. [10] |
83 adults 136 children biopsy-proven nephritis |
Dialysis-dependency: 13% of adults, 7% of children Severe renal impairmentc: 10% of adults, 5% of children Moderate renal impairmentd: 15% of adults, 12% of children Moderate proteinuria with normal renal function: 15% of adults, 12% of children Proteinuria ≤1 g/24 h with normal renal function: 40% of adults, 45% of children Nephrotic-range proteinuria: 2% of adults, 4% of children |
4.5 years median |
| Pillebout et al. [11] |
250 adults biopsy-proven nephritis |
ESRD: 11% Severe renal insufficiencye: 13% Moderate renal insufficiencyf: 14% Renal remissiong: 20% Nephrotic-range proteinuria: 8% Non-nephrotic proteinuria: 47% Haematuria: 50% |
14.8 years median |
| Shrestha et al. [12] |
37 adults biopsy-proven nephritis |
Clinical remissionh: 43% ESRD: 27% Renal insufficiencyi: 8% Proteinuria with normal renal function: 19% |
9.4 ± 7.1 years mean ± SD |
| Rauta et al. [13] |
38 adults biopsy-proven nephritis |
Normal serum creatinine + absence of haematuria + absence of proteinuria: 12% ESRD: 11% Proteinuria: 45% Nephrotic-range proteinuria: 3% |
6.1 ± 4.3 years mean ± SD |
Plasma creatinine >125% upper limit of normal.
Plasma creatinine 1.6–2.4 mg/dL.
Serum creatinine >3 mg/dL in adults and CrCl <60 mL/min/1.73 m2 (Schwartz formula) in children.
Serum ceatinine >1.5 mg/dL and ≤3 mg/dL in adults, and CrCl <90 mL/min/1.73 m2 and ≥60 mL/min/1.73 m2 (Schwartz formula) in children.
CrCl <30 mL/min (Cockroft and Gault formula).
CrCl <50 mL/min and CrCl ≥30 mL/min (Cockroft and Gault formula).
CrCl ≥50 mL/min + absence of proteinuria + absence of haematuria.
Absence of extra-renal involvement + creatinine <120 μmol/L in females, <130 μmol/L in males + absence of significant haematuria (≤1 × 106/24 h in males, ≤2 × 106/24 h in females) and/or proteinuria (<0.3 g/24 h).
Creatinine ≥120 μmol/L in females, ≥130 μmol/L in males. ESRD, end-stage renal disease; CrCl, creatinine clearance.