Table 2.
Mean change from baseline in vital signs and hematologic evaluations following QD treatment with SZC 5 or 10 g for 4 days
| SZC 5 g QD (n = 15) | SZC 10 g QD (n = 15) | |
|---|---|---|
| Systolic blood pressure, mmHg | ||
| Baseline | 125.30 ± 11.60 | 127.70 ± 10.17 |
| Study Day 9 | 122.30 ± 8.66 | 121.10 ± 10.32 |
| Change to study Day 9 (95% CI) | −3.1 ± 13.31 (−10.40, 4.30) | −6.5 ± 13.83 (−14.20, 1.10) |
| Diastolic blood pressure, mmHg | ||
| Baseline | 79.30 ± 7.78 | 81.30 ± 4.65 |
| Study Day 9 | 73.10 ± 5.72 | 76.70 ± 6.20 |
| Change to study Day 9 (95% CI) | −6.1 ± 7.03 (−10.00, −2.20) | −4.6 ± 7.73 (−8.90, −0.30) |
| Body weight, kg | ||
| Baseline | 81.17 ± 20.01 | 82.37 ± 13.19 |
| Study Day 9 | 78.55 ± 19.31 | 79.97 ± 12.15 |
| Change to study Day 9 (95% CI) | −2.61 ± 1.85 (−3.64, −1.59) | −2.39 ± 1.39 (−3.16, −1.62) |
| Hemoglobin, g/dL | ||
| Baseline | 14.76 ± 0.95 | 14.33 ± 1.37 |
| Study Day 9 | 15.05 ± 1.02 | 14.50 ± 1.12 |
| Change to study Day 9 (95% CI) | 0.29 ± 0.72 (−0.11, 0.68) | 0.17 ± 0.79 (−0.27, 0.60) |
| Hematocrit, % | ||
| Baseline | 45.87 ± 2.67 | 44.55 ± 3.70 |
| Study Day 9 | 46.45 ± 3.12 | 45.58 ± 3.68 |
| Change to study Day 9 (95% CI) | 0.58 ± 2.45 (−0.78, 1.94) | 1.03 ± 2.94 (−0.60, 2.66) |
Data are mean ± SD unless stated otherwise.