Table 4.
IRs and adjusted HRs for incident CVD according to cross categories of obesity phenotypes and hs-cTnT levels, N = 9,477
| Metabolic status† | Obesity status | hs-cTnT level, ng/L | Events/n | IR/1,000 person-years (95% CI) | Adjusted,* HR (95% CI) |
|---|---|---|---|---|---|
| Metabolically healthy | Normal weight | <6 ng/L | 265/1,606 | 7.4 (6.6–8.4) | 1 (Reference) |
| ≥6 ng/L | 93/336 | 14.2 (11.6–17.4) | 1.48 (1.17–1.88) | ||
| Overweight | <6 ng/L | 253/1,364 | 8.4 (7.5–9.5) | 1.09 (0.92–1.30) | |
| ≥6 ng/L | 111/361 | 15.2 (12.6–18.3) | 1.53 (1.22–1.92) | ||
| Obese | <6 ng/L | 113/545 | 9.4 (7.79–11.3) | 1.37 (1.10–1.71) | |
| ≥6 ng/L | 52/151 | 17.1 (13.0–22.4) | 1.95 (1.44–2.64) | ||
| Metabolically unhealthy | Normal weight | <6 ng/L | 207/788 | 12.9 (11.2–14.8) | 1.49 (1.24–1.79) |
| ≥6 ng/L | 124/285 | 25.7 (21.4–30.5) | 2.23 (1.78–2.80) | ||
| Overweight | <6 ng/L | 454/1,571 | 13.9 (12.7–15.2) | 1.56 (1.33–1.81) | |
| ≥6 ng/L | 286/641 | 24.4 (21.7–27.4) | 2.38 (2.00–2.83) | ||
| Obese | <6 ng/L | 376/1,244 | 14.8 (13.4–16.4) | 2.04 (1.74–2.40) | |
| ≥6 ng/L | 269/581 | 27.5 (24.4–31.0) | 3.06 (2.57–3.65) |
Boldface type indicates P < 0.05. IR, incidence rate.
*
Adjustment for age, sex, race-center, smoking status, physical activity, hs-CRP, eGFR, and NT-proBNP.
†
Metabolic healthy, fewer than two Adult Treatment Panel III criteria; metabolically unhealthy, two or more Adult Treatment Panel III criteria.