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. 2021 Jul 29;14:118. doi: 10.1186/s13045-021-01128-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — 7 × 19 CAR-T cells showed remarkable antitumor activity in HCC and PC patients with GPC3 and MSLN expression. For patient GD-G/M-001, three metastatic lesions were chosen to perform fine needles CT-guided intratumor injection of CAR-T cells. a One nodule (0.5 cm) in the right front lung, injected with anti-GPC3 CAR-T cells as a comparison; the second nodule (0.5 cm) in the right back lung, injected with anti-GPC3-7 × 19 CAR-T cells. The results showed that the inhibited growth of anti-GPC3-7 × 19 and anti-GPC3 CAR-T cells at similar levels 60 days after injection. Tumor is indicated by white arrow. b For the same patient GD-G/M-001, a tumor close to the gallbladder (1.7 × 2.0 cm) was fine needle punctured under CT guidance and injected with anti-GPC3-7 × 19 CAR-T cells. 10- and 32-day follow-up CT scans showed a significant decrease in the size of the lesion and finally disappeared, respectively. At the same time, injection of the same CAR-T cells into the portal vein resulted in partial reopening of the previously obstructed portal vein. Metastatic tumor is indicated by white cycle; primary tumor is indicated by red cycle; white arrow points fine needle. c PET-CT and CT scans demonstrated a hepatic hilar lymph node metastasis after primary pancreatic carcinoma surgery in complete response in patient GD-G/M-005 following one intraartery and four intravein administrations of the autologous anti-MSLN-7 × 19 CAR-T cell infusion products. Tumor is indicated by red cycle